Article
Relationship of mitochondrial DNA depletion and respiratory chain activity in preadipocytes treated with nucleoside reverse transcriptase inhibitors.
Antiviral therapy - 1 Jan 2007
Stankov Metodi V, Lücke Thomas, Das Anibh M, Schmidt Reinhold E, Behrens Georg M N
Abstract excerpt
OBJECTIVE: To study the impact of adipocyte differentiation on nucleoside reverse transcriptase inhibitor (NRTI)-mediated mitochondrial DNA (mtDNA) depletion and to correlate mtDNA depletion with the activity of the respiratory chain complexes. METHODS: We studied adipocyte phenotype, viability, differentiation (CCAAT/enhancer-binding protein [C/EBP]-alpha and peroxisome proliferator-activated receptor...
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