Article
The -374A allele of the receptor for advanced glycation end products (RAGE) gene promoter is a protective factor against cardiovascular lesions in type 2 diabetes mellitus patients.
Clinical chemistry and laboratory medicine - 1 Jan 2007
Picheth Geraldo, Costantini Costantino O, Pedrosa Fábio O, Leme da Rocha Martinez Tania, Maltempi de Souza Emanuel
Abstract excerpt
BACKGROUND: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been associated with diabetes, coronary artery disease (CAD) and inflammatory processes. The -374T >A RAGE gene promoter polymorphism was shown to affect gene transcription. The aim of this study was to evaluate the association of the -374T >A polymorphism with the severity of CAD in patients with or without type 2...
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