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Article

Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.

PLoS genetics - 1 Jan 2012

Ohno Genta, Ono Kanako, Togo Marina, Watanabe Yohei, Ono Shoichiro, Hagiwara Masatoshi, Kuroyanagi Hidehito

Abstract excerpt

Pre-mRNAs are often processed in complex patterns in tissue-specific manners to produce a variety of protein isoforms from single genes. However, mechanisms orchestrating the processing of the entire transcript are not well understood. Muscle-specific alternative pre-mRNA processing of the unc-60 gene in Caenorhabditis elegans, encoding two tissue-specific isoforms of ADF/cofilin with distinct biochemical...

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Identifiers

PMID: 23071450
DOI: 10.1371/journal.pgen.1002991
PMCID: PMC3469465

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.PMID 23071450Read ↗

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Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform.Semantic proximity Read ↗

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