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Using DNA sequencing electrophoresis compression artifacts as reporters of stable mRNA structures affecting gene expression.

Electrophoresis - 1 Nov 2007

Kapoor Divya, Chandrayan Sanjeev Kumar, Ahmed Shubbir, Guptasarma Purnananda

Abstract excerpt

The formation of secondary structure in oligonucleotide DNA is known to lead to "compression" artifacts in electropherograms produced through DNA sequencing. Separately, the formation of secondary structure in mRNA is known to suppress translation; in particular, when such structures form in a region covered by the ribosome either during, or shortly after, initiation of translation. Here, we demonstrate how a DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17922510
DOI: 10.1002/elps.200700359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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