Article
Caprine herpesvirus 1 vaccine with the LTK63 mutant as a mucosal adjuvant induces strong protection against genital infection in goats.
Vaccine - 14 Nov 2007
Tempesta M, Camero M, Bellacicco A L, Tarsitano E, Lorusso A, Martella V, Decaro N, Del Giudice G, Cassone A, Quaranta A, Buonavoglia C
Abstract excerpt
Caprine herpesvirus 1 provides a unique virus-animal model to investigate potential tools applicable for the therapy and prophylaxis of genital herpesvirus infections of humans. In order to evaluate the efficacy of mucosal immunization in the goat model, an inactivated CpHV-1 vaccine was adjuvated with the enzymatically inactive mutant of the heat-labile enterotoxin of Escherichia coli, LTK63, and used to...
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