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Article

A multi‐subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN‐γ+ CMI responses protects against a genital infection in minipigs

13 Aug 2015

Abstract excerpt

Chlamydia is the most widespread sexually transmitted bacterial disease and a prophylactic vaccine is highly needed. Ideally, this vaccine is required to induce a combined response of Th1 cell-mediated immune (CMI) response in concert with neutralizing antibodies. Using a novel Göttingen minipig animal model, we evaluated the immunogenicity and efficacy of a multi-subunit vaccine formulated in the strong...

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PMID: 26268662
DOI: 10.1038/icb.2015.79

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