Article
Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness.
Molecular biology reports - 1 Jan 2009
Sfar Sana, Saad Hamadi, Mosbah Faouzi, Chouchane Lotfi
Abstract excerpt
The single-gene approaches in association studies of polygenic diseases are likely to provide limited value in predicting risk. The combined analysis of genetic variants that interact in the same pathway may amplify the effects of individual polymorphisms and enhance the predictive power. To evaluate higher order gene-gene interaction, we have examined the contribution of four angiogenic gene polymorphisms...
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