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Article

Novel Orbital Shake Bioreactors for Transient Production of CHO Derived IgGs

3 Oct 2007

Abstract excerpt

Large-scale transient gene expression in mammalian cells is being developed for the rapid production of recombinant proteins for biochemical and preclinical studies. Here, the scalability of transient production of a recombinant human antibody in Chinese hamster ovary (CHO) cells was demonstrated in orbitally shaken disposable bioreactors at scales from 50 mL to 50 L. First, a small-scale multiparameter approach...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 17914862
DOI: 10.1021/bp070219i

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