Article
KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities.
The Journal of allergy and clinical immunology - 1 Sept 2007
Maric Irina, Robyn Jamie, Metcalfe Dean D, Fay Michael P, Carter Melody, Wilson Todd, Fu Weiming, Stoddard Jennifer, Scott Linda, Hartsell Marilyn, Kirshenbaum Arnold, Akin Cem, Nutman Thomas B, Noel Pierre, Klion Amy D
Abstract excerpt
BACKGROUND: The broad and overlapping clinical manifestations of D816V KIT-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia (CEL), coupled with the increase in activated eosinophils and mast cells seen in both disorders, have led to confusion in the nomenclature. It is of paramount importance, however, to distinguish between these 2 groups of patients...
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