Article
FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature.
Leukemia research - 1 Aug 2006
Pardanani A, Ketterling R P, Li C-Y, Patnaik M M, Wolanskyj A P, Elliott M A, Camoriano J K, Butterfield J H, Dewald G W, Tefferi A
Abstract excerpt
We previously studied clinico-pathologic features of 89 consecutive adult patients with moderate-to-severe eosinophilia, and reported a FIP1L1-PDGFRA prevalence of 12%. In that series, all 11 FIP1L1-PDGFRA+ patients receiving imatinib achieved a complete response. We now extend our observations through a study of 741 unselected patients with eosinophilia for FIP1L1-PDGFRA, and present longer term follow up data...
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