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Article

FIP1L1-PDGFRalpha alone or with other genetic abnormalities reveals disease progression in chronic eosinophilic leukemia but good response to imatinib.

Chinese medical journal - 20 May 2008

Wang Lin-na, Pan Qin, Fu Jian-fei, Shi Jing-yi, Jin Jie, Li Jun-ming, Hu Jiong, Zhao Wei-li, Chen Zhu, Chen Sai-juan

Abstract excerpt

BACKGROUND: The FIP1L1-PDGFRalpha fusion gene plays an important role in the pathogenesis of chronic eosinophilic leukemia (CEL) and is a direct therapeutic target of the tyrosine kinase inhibitor imatinib mesylate. METHODS: In 24 hypereosinophilic syndromes (HES) patients, using reverse transcri...

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Share to Benzamides
Share to fms-Like Tyrosine Kinase 3
Share to Hypereosinophilic Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Imatinib Mesylate

Share to mRNA Cleavage and Polyadenylation Factors

Share to Oncogene Proteins, Fusion

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 18706197

Genes

CEL
FLT3
FGFR1
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18706197-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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