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Article

A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS.

Human molecular genetics - 15 Jun 2015

Nagano Seiichi, Takahashi Yoko, Yamamoto Kazuhiro, Masutani Hiroshi, Fujiwara Noriko, Urushitani Makoto, Araki Toshiyuki

Abstract excerpt

We previously showed by in vitro experiments that the cysteine residue (Cys111) near the dimer interface is critical for monomerization and resultant aggregate formation of mutant Cu, Zn-superoxide dismutase (SOD1) protein, which is toxic to motor neurons in familial amyotrophic lateral sclerosis...

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Source

Identifiers

PMID: 25762155
DOI: 10.1093/hmg/ddv093

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25762155-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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