Article
Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer.
Cancer research - 1 Oct 2007
Berwick Marianne, Satagopan Jaya M, Ben-Porat Leah, Carlson Ann, Mah Katherine, Henry Rashida, Diotti Raffaella, Milton Kelly, Pujara Kanan, Landers Tom, Dev Batish Sat, Morales José, Schindler Detlev, Hanenberg Helmut, Hromas Robert, Levran Orna, Auerbach Arleen D
Abstract excerpt
Fanconi anemia (FA) is a rare autosomal recessive disease characterized by a greatly increased risk of cancer among those diagnosed with the syndrome. The question as to whether FA heterozygotes are at increased risk for cancer is of great importance to those at risk for being a carrier. To address this question, we formed a cohort of grandparents of probands identified through the International Fanconi Anemia...
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