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Article

Multiple Primary Cancers in Families With Li-Fraumeni Syndrome

15 Apr 1998

Abstract excerpt

BACKGROUND: Li-Fraumeni syndrome is a dominantly inherited disorder characterized by early-onset breast cancer, sarcomas, and other cancers in children and young adults. Members of families with this syndrome also develop multiple primary cancers, but the frequency is unknown. To approach this issue, we quantified the incidence of second and third primary cancers in individuals from 24 Li-Fraumeni kindreds...

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PMID: 9554443
DOI: 10.1093/jnci/90.8.606

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