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Article

Risk of cancer in heterozygous relatives of patients with Fanconi anemia.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2022

McReynolds Lisa J, Giri Neelam, Leathwood Lisa, Risch Maureen O, Carr Ann G, Alter Blanche P

Abstract excerpt

PURPOSE: Fanconi anemia (FA) is a cancer-prone inherited bone marrow failure syndrome caused by biallelic pathogenic variants in one of >22 genes in the FA/BRCA DNA repair pathway. A major concern is whether the risk of cancer is increased in individuals with a single pathogenic FA gene variant. METHODS: We evaluated the risk of cancer in the relatives of patients with FA in the National Cancer Institute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34906449
DOI: 10.1016/j.gim.2021.08.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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