Article
Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.
Antimicrobial agents and chemotherapy - 1 Dec 2007
Chau Tran Thuy, Campbell James Ian, Galindo Claudia M, Van Minh Hoang Nguyen, Diep To Song, Nga Tran Thu Thi, Van Vinh Chau Nguyen, Tuan Phung Quoc, Page Anne Laure, Ochiai R Leon, Schultsz Constance, Wain John, Bhutta Zulfiqar A, Parry Christopher M, Bhattacharya Sujit K, Dutta Shanta, Agtini Magdarina, Dong Baiqing, Honghui Yang, Anh Dang Duc, Canh Do Gia, Naheed Aliya, Albert M John, Phetsouvanh Rattanaphone, Newton Paul N, Basnyat Buddha, Arjyal Amit, La Tran Thi Phi, Rang Nguyen Ngoc, Phuong Le Thi, Van Be Bay Phan, von Seidlein Lorenz, Dougan Gordon, Clemens John D, Vinh Ha, Hien Tran Tinh, Chinh Nguyen Tran, Acosta Camilo J, Farrar Jeremy, Dolecek Christiane
Abstract excerpt
This study describes the pattern and extent of drug resistance in 1,774 strains of Salmonella enterica serovar Typhi isolated across Asia between 1993 and 2005 and characterizes the molecular mechanisms underlying the reduced susceptibilities to fluoroquinolones of these strains. For 1,393 serovar Typhi strains collected in southern Vietnam, the proportion of multidrug resistance has remained high since 1993 (50%...
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