Article
Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2008
Koller Daniel L, Liu Lixiang, Alam Imranul, Sun Qiwei, Econs Michael J, Foroud Tatiana, Turner Charles H
Abstract excerpt
UNLABELLED: To further delineate the factors underlying the complex genetic architecture of BMD in the rat model, a genome screen for epistatic interactions was conducted. Several significant interactions were identified, involving both previously identified and novel QTLs. INTRODUCTION: The variation in several of the risk factors for osteoporotic fracture, including BMD, has been shown to be caused largely by...
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