Article
G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study.
American journal of hypertension - 1 Oct 2007
Bhuiyan Azad R, Chen Wei, Srinivasan Sathanur R, Rice Janet, Mock Nancy, Tang Rong, Bond M Gene, Boerwinkle Eric, Berenson Gerald S
Abstract excerpt
BACKGROUND: The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this relationship is unknown. METHODS: In 662 white and black subjects aged 25 to 43 years (73.4%...
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