Article
G-6A polymorphism of the angiotensinogen gene and its association with left ventricular mass in asymptomatic young adults from a biethnic community: the Bogalusa Heart Study.
American journal of hypertension - 1 Nov 2005
Patel Dharmendrakumar A, Li Shengxu, Chen Wei, Srinivasan Sathanur R, Boerwinkle Eric, Berenson Gerald S
Abstract excerpt
BACKGROUND: Angiotensinogen (AGT), the precursor of angiotensin II and a rate limiting factor in the renin-angiotensin system, is implicated in left ventricular hypertrophy, as angiotensin II is a potent stimulator of cardiac growth. A genetic variant (G-6A) in the proximal promoter region of the AGT gene may be particularly important for changes in left ventricular mass (LVM). However, previous findings...
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