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Article

Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype.

Breast cancer research : BCR - 1 Jan 2009

Roarty Kevin, Baxley Sarah E, Crowley Michael R, Frost Andra R, Serra Rosa

Abstract excerpt

INTRODUCTION: The tumour-suppressive effects of transforming growth factor-beta (TGF-beta) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonical member of the Wingless-related protein family, Wnt5a, is required for TGF-beta-mediated effects on mammary development. Several lines of evidence support the hypothesis that Wnt5a acts as...

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Share to Mammary Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Transforming Growth Factor-beta Type II

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Source

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Identifiers

PMID: 19344510
DOI: 10.1186/bcr2244
PMCID: PMC2688948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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