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Article

The tetramerization domain of p53 is required for efficient BAK oligomerization.

Cancer biology & therapy - 1 Oct 2007

Pietsch E Christine, Leu J I-Ju, Frank Amanda, Dumont Patrick, George Donna L, Murphy Maureen E

Abstract excerpt

In addition to a well-defined transcriptional activity that is necessary for efficient apoptosis induction, the p53 tumor suppressor also has a direct apoptogenic role at the mitochondria. This direct role in cell death is mediated at least in part by interaction of p53 with BCL2 family members,...

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Share to Apoptosis
Share to bcl-2 Homologous Antagonist-Killer Protein
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Mice, Mutant Strains

Share to Mitochondria

Share to Sequence Deletion

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17895645
DOI: 10.4161/cbt.6.10.4719

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17895645-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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