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Article

The tetramerization domain of p53 is required for efficient BAK oligomerization.

Cancer biology & therapy - 1 Oct 2007

Pietsch E Christine, Leu J I-Ju, Frank Amanda, Dumont Patrick, George Donna L, Murphy Maureen E

Abstract excerpt

In addition to a well-defined transcriptional activity that is necessary for efficient apoptosis induction, the p53 tumor suppressor also has a direct apoptogenic role at the mitochondria. This direct role in cell death is mediated at least in part by interaction of p53 with BCL2 family members, including the pro-apoptotic protein BAK. Whereas it is currently accepted that the mitochondrial function of p53...

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Share to Apoptosis
Share to bcl-2 Homologous Antagonist-Killer Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17895645
DOI: 10.4161/cbt.6.10.4719

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The tetramerization domain of p53 is required for efficient BAK oligomerization.PMID 17895645Read ↗

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