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Article

TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

Hoarau Cyrille, Gérard Bénédicte, Lescanne Emmanuel, Henry Dominique, François Stéphanie, Lacapère Jean-Jacques, El Benna Jamel, Dang Pham My-Chan, Grandchamp Bernard, Lebranchu Yvon, Gougerot-Pocidalo Marie-Anne, Elbim Carole

Abstract excerpt

Polymorphonuclear neutrophils (PMN) play a key role in innate immunity. Their activation and survival are tightly regulated by microbial products via pattern recognition receptors such as TLRs, which mediate recruitment of the IL-1R-associated kinase (IRAK) complex. We describe a new inherited IRAK-4 deficiency in a child with recurrent pyogenic bacterial infections. Analysis of the IRAK4 gene showed compound...

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Cell Adhesion
Interleukin-1
Interleukin-1 Receptor-Associated Kinases
Interleukin-18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 3-Kinases

Toll-Like Receptor 9

Source

Identifiers

PMID: 17878374
DOI: 10.4049/jimmunol.179.7.4754

Genes

TLR9
IRAK4
TLR1
TLR2
TLR4
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.PMID 17878374Read ↗

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.Semantic proximity Read ↗

Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant.Semantic proximity Read ↗

Pyogenic bacterial infections in humans with IRAK-4 deficiency.Semantic proximity Read ↗

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Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice.Semantic proximity Read ↗

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A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.Semantic proximity Read ↗

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