Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types

Abstract excerpt

Inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene results in the development of schwannomas and meningiomas. Using NF2-deficient meningioma cells and tumors, together with the normal cellular counterparts that meningiomas derive, arachnoid cells, we identified merlin as a novel negative regulator of mTOR complex 1 (mTORC1). We now show that merlin positively regulates the kinase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hippo pathway signaling and YAP/TAZ
• Share to Neurofibromatosis and Schwannoma Cases
• Share to Tuberous Sclerosis Complex Research