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Article

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode.

Biochemical and biophysical research communications - 23 Nov 2007

Barreca Maria Letizia, Ortuso Francesco, Iraci Nunzio, De Luca Laura, Alcaro Stefano, Chimirri Alba

Abstract excerpt

The targeting of HIV-1 integrase (IN) for the design of novel antiviral compounds has until now proceeded slowly, mainly due to the lack of three-dimensional structures reporting detail interactions between IN and its DNA substrates as well as the complete enzyme with its three domains. Recently, we have proposed that Tn5 transposase (Tnp) can be used as a useful surrogate model for IN in attempt to address the...

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Identifiers

PMID: 17889829
DOI: 10.1016/j.bbrc.2007.08.199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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