Article
Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication.
Antiviral research - 1 Jan 2008
Korba Brent E, Montero Abigail B, Farrar Kristine, Gaye Karen, Mukerjee Sampa, Ayers Marc S, Rossignol Jean-François
Abstract excerpt
Nitazoxanide (NTZ), a thiazolide anti-infective, is active against anaerobic bacteria, protozoa, and a range of viruses in cell culture models, and is currently in phase II clinical development for treating chronic hepatitis C. In this report, we characterize the activities of NTZ and its active metabolite, tizoxanide (TIZ), along with other thiazolides against hepatitis B virus (HBV) and hepatitis C virus (HCV)...
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