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Article

Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers.

Genes, chromosomes & cancer - 1 Dec 2007

Lewis Kriste A, Bakkum-Gamez Jamie, Loewen Ralitsa, French Amy J, Thibodeau Stephen N, Cliby William A

Abstract excerpt

In response to certain types of DNA damage, ataxia telangiectasia and rad3-related (ATR) phosphorylates checkpoint kinase 1 (CHEK1) resulting in cell cycle arrest and subsequent DNA repair. ATR and CHEK1 contain mononucleotide microsatellite repeat regions, which are mutational targets in tumors...

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Source

Identifiers

PMID: 17879369
DOI: 10.1002/gcc.20486

Genes

ATR
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17879369-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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