Article
Polymorphisms at the osteoprotegerin and interleukin-6 genes in relation to first-ever stroke.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2007
Strand Magnus, Soderstrom Ingegerd, Wiklund Per-Gunnar, Hallmans Goran, Weinehall Lars, Soderberg Stefan, Olsson Tommy
Abstract excerpt
BACKGROUND: Arterial calcification and osteoporosis often coexist, especially in postmenopausal women. Osteoporosis associates with a substantially increased risk of stroke in elderly women, suggesting that impaired estrogen signaling may link stroke and osteoporosis. Osteoprotegerin (OPG, TNFRSF11B) and interleukin-6 (IL-6, IL6) are putative target genes for estrogen signaling and have been implicated in both...
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