Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational studies of CXCR1, the receptor of IL-8/CXCL8, using molecular dynamics and electrostatics.

Biopolymers - 1 Jan 2008

Huynh Nicholas, Mallik Buddhadeb, Zhang Li, Martins-Green Manuela, Morikis Dimitrios

Abstract excerpt

The three-dimensional structure of IL-8/CXCL8 has been previously determined using NMR spectroscopy and X-ray crystallography, but the structure of the receptors for this chemokine has not been determined experimentally. We present here the development of a model for the structure of the IL-8/CXCL8 receptor CXCR1, using a combination of homology modeling and a molecular dynamics simulation. Based on this model,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-8

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Protein Conformation

Share to Receptors, Interleukin-8A

Share to Static Electricity

Source

Identifiers

PMID: 17876799
DOI: 10.1002/bip.20851

Genes

CXCR1
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational studies of CXCR1, the receptor of IL-8/CXCL8, using molecular dynamics and electrostatics.PMID 17876799Read ↗

A structural and dynamic model for the interaction of interleukin-8 and glycosaminoglycans: support from isothermal fluorescence titrations.Semantic proximity Read ↗

Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.Semantic proximity Read ↗

Mutational Analysis of Interleukin-11 and its Consequences on Cancer and COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics StudySemantic proximity Read ↗

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design.Semantic proximity Read ↗

Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.Semantic proximity Read ↗

Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potentialSemantic proximity Read ↗

Multiple interests in structural models of DARC transmembrane protein.Semantic proximity Read ↗

Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11R/G31P.Semantic proximity Read ↗

Insight into the modified Ibalizumab-human CD4 receptor interactions: using a computational binding free energy approach.Semantic proximity Read ↗

Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonistsSemantic proximity Read ↗

Conservation of unfavorable sequence motifs that contribute to the chemokine quaternary state.Semantic proximity Read ↗

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.