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Article

Design and optimization of SPR-based binding assay for evaluation and screening of MITF-E-box binding inhibitor.

Molecular biotechnology - 1 Mar 2014

Morya V K, Son Manki, Lee Hyang-Bok, Eun-ki Eun-ki

Abstract excerpt

Melanin synthesis is a complex phenomenon which involves about 192 known gene products. Among them, MITF is a key transcription factor for tyrosinase, Trp1 and Trp2 proteins, which are essential for melanin biosynthesis. Thus, intervening inhibitor for the MITF-E-box complex formation can downregulate melanin synthesis. The focus of the present study is to develop a surface plasmon resonance-based system to...

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Source

Identifiers

PMID: 24078219
DOI: 10.1007/s12033-013-9705-1

Genes

MITF
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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