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Article

Wobble inosine tRNA modification is essential to cell cycle progression in G(1)/S and G(2)/M transitions in fission yeast.

The Journal of biological chemistry - 16 Nov 2007

Tsutsumi Satoshi, Sugiura Reiko, Ma Yan, Tokuoka Hideki, Ohta Kazuki, Ohte Rieko, Noma Akiko, Suzuki Tsutomu, Kuno Takayoshi

Abstract excerpt

Inosine (I) at position 34 (wobble position) of tRNA is formed by the hydrolytic deamination of a genomically encoded adenosine (A). The enzyme catalyzing this reaction, termed tRNA A:34 deaminase, is the heterodimeric Tad2p/ADAT2.Tad3p/ADAT3 complex in eukaryotes. In budding yeast, deletion of e...

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Source

Identifiers

PMID: 17875641
DOI: 10.1074/jbc.M706869200

Genes

ADAT2
ADAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17875641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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