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Article

Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells

14 Sept 2007

Abstract excerpt

OBJECTIVES: West Nile virus (WNV) infection causes severe meningitis and encephalitis in a subset of patients. WNV-induced apoptosis has been suggested to contribute to WNV pathogenesis. Tetracyclines exert antiviral effects against HIV and inhibit apoptosis in different models of neuronal disease. Here, the effects of the tetracyclines minocycline, demeclocycline and chlortetracycline were observed on WNV...

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PMID: 17872917
DOI: 10.1093/jac/dkm307

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