Article

Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders

2025-06-27

Abstract excerpt

The pleiotropy of minocycline (MINO), including anti-inflammatory, antioxidant, anti-migratory, anti-MMP, and neuroprotective effects, has been extensively reported. A novel non-antibiotic minocycline derivative, 10-butyl ether minocycline (BEM), was synthesized to retain the pleiotropy of minocycline while minimizing side effects such as antibiotic resistance and gut dysbiosis. Previously, we showed that BEM redu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b025269-68da-5560-b293-6cdf9d830f54
DOI: 10.1101/2025.06.23.661183

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disordersDOI 10.1101/2025.06.23.661183Read

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic HealthSemantic proximity Read

Minocycline in Acute Traumatic Spinal Cord Injury: A Systematic Review and Exploratory Meta-Analysis of Preclinical and Clinical EvidenceSemantic proximity Read

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfoldingSemantic proximity Read

Normal aging hyperactivates innate immunity and reduces the medical efficacy of minocycline in brain injurySemantic proximity Read

Uncovering the mechanism of action of a historical antimicrobial against <i>S. aureus</i> and <i>A. baumannii</i>Semantic proximity Read

Geraniol, a Potential Alternative to Antibiotics for Bovine Mastitis Treatment Without Disturbing the Host Microbial Community, Does Not Lead to Drug Residues or Induce Drug ResistanceSemantic proximity Read

Myxobacterial secondary metabolites: bioactivities and modes-of-actionSemantic proximity Read

Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.Semantic proximity Read

Repurposing Monensin for Inflammation and Immunity: A Comprehensive ReviewSemantic proximity Read

Biotic acts of antibioticsSemantic proximity Read

Anti-Virulence Activity of 3,3′-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing BenefitsSemantic proximity Read

The history of the tetracyclinesSemantic proximity Read