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Article

Minocycline for Huntington’s disease: An open label study

11 Mar 2003

Abstract excerpt

Despite advances in understanding the pathogenesis of Huntington’s disease (HD), there is no effective treatment. In the HD transgenic mouse, expression of a dominant-negative caspase-1 mutant extended survival and delayed the onset of symptoms, suggesting that caspase-1 is crucial in HD pathogenesis.1 In fact, the caspase inhibitor minocycline delayed disease progression and extended survival by 14% in the HD...

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PMID: 12629257
DOI: 10.1212/01.wnl.0000049936.85487.7a

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