Article
Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma.
Human immunology - 1 Sept 2007
Ben Nasr Hela, Chahed Karim, Mestiri Souhir, Bouaouina Noureddine, Snoussi Kaouther, Chouchane Lotfi
Abstract excerpt
Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies including nasopharyngeal carcinoma (NPC). In the present study, we evaluated the susceptibility and prognostic implications of the (-251) T/A genetic variation in IL-8 in NPC. We used the allele-specific polymerase chain reaction to characterize the variation of the IL-8 promoter...
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