Article
Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression.
FEMS microbiology letters - 1 Oct 2007
Bergval Indra L, Klatser Paul R, Schuitema Anja R J, Oskam Linda, Anthony Richard M
Abstract excerpt
In Mycobacterium tuberculosis (MTB), rifampicin resistance is almost invariably due to mutations in the rpoB gene, whose function is critical for cell viability. Most of these mutations, at least initially, impair the fitness of the bacteria but confer a selective advantage when antibiotic pressu...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.