Article
Cystic fibrosis: production of high levels of uromodulin-like protein by HLA-DR blood monocytes differentiating towards a fibroblastic phenotype.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 1991
Labat M L, Bringuier A F, Seebold-Choqueux C, Moricard Y, Rault G, Jehanne M, Ferrec C, Milhaud G
Abstract excerpt
We report here the spontaneous in vitro transformation of blood monocytes into fibroblasts, in a patient suffering from cystic fibrosis (CF). The blood monocytes with this capacity express HLA-DR specificity. Monocytes were identified by non-specific esterase activity and by immunofluorescence using monoclonal antibodies against monocytes/macrophages antigens. Neo-fibroblasts were identified by electron...
Topics
- Adolescent
- Cell Line, Transformed
- Cystic Fibrosis
- Fibroblasts
- Fluorescent Antibody Technique
- HLA-DR Antigens
- Humans
- In Vitro Techniques
- Male
- Microscopy, Electron