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Article

Distal axonopathy in an alsin-deficient mouse model.

Human molecular genetics - 1 Dec 2007

Deng Han-Xiang, Zhai Hong, Fu Ronggen, Shi Yong, Gorrie George H, Yang Yi, Liu Erdong, Dal Canto Mauro C, Mugnaini Enrico, Siddique Teepu

Abstract excerpt

Mutations in Alsin are associated with chronic juvenile amyotrophic lateral sclerosis (ALS2), juvenile primary lateral sclerosis and infantile-onset ascending spastic paralysis. The primary pathology and pathogenic mechanism of the disease remain largely unknown. Here we show that alsin-deficient...

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Source

Identifiers

PMID: 17855450
DOI: 10.1093/hmg/ddm251

Genes

ALS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17855450-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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