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Mechanistic and functional aspects of the Ruminococcin C sactipeptide isoforms

6 Aug 2023

Abstract excerpt

In a scenario where the discovery of new molecules to fight antibiotic resistance is a public health concern, ribosomally synthesized and post-translationally modified peptides constitute a promising alternative. In this context, the Gram-positive human gut symbiont Ruminococcus gnavus E1 produces five sactipeptides, Ruminococcins C1 to C5 (RumC1–C5), co-expressed with two radical SAM maturases. RumC1 has been...

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PMID: 37664601
DOI: 10.1016/j.isci.2023.107563

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