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Article

Identification and characterization of bifunctional proline racemase/hydroxyproline epimerase from archaea: discrimination of substrates and molecular evolution.

PloS one - 1 Jan 2015

Watanabe Seiya, Tanimoto Yoshiaki, Nishiwaki Hisashi, Watanabe Yasuo

Abstract excerpt

Proline racemase (ProR) is a member of the pyridoxal 5'-phosphate-independent racemase family, and is involved in the Stickland reaction (fermentation) in certain clostridia as well as the mechanisms underlying the escape of parasites from host immunity in eukaryotic Trypanosoma. Hydroxyproline epimerase (HypE), which is in the same protein family as ProR, catalyzes the first step of the trans-4-hydroxy-L-proline...

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Identifiers

PMID: 25786142
DOI: 10.1371/journal.pone.0120349
PMCID: PMC4364671

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