Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage and repair in human lymphocytes exposed to three anticancer platinum drugs

1 Jan 2000

Abstract excerpt

Cisplatin is a widely used anticancer drug, but its application is limited due to severe side effects. To reduce these effects, many other platinum drugs have been synthesized. In the present work comparative analysis of the toxicity of cisplatin, oxoplatin, and a conjugate (NH(3))(2)Pt(SeO(3)) (Se-Pt) in terms of cell viability, DNA binding, and DNA damage and repair in human lymphocytes was performed using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Metal complexes synthesis and properties
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10820422
DOI: 10.1002/(sici)1520-6866(2000)20:3<119::aid-tcm3>3.0.co;2-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage and repair in human lymphocytes exposed to three anticancer platinum drugsPMID 10820422Read ↗

Cisplatin Is a DNA-Damaging Antitumour Compound Triggering Multifactorial Biochemical Responses in Cancer Cells: Importance of Apoptotic PathwaysSemantic proximity Read ↗

Vitamin E protects against cisplatin-induced genotoxicity in human lymphocytesSemantic proximity Read ↗

Biomolecular Targets for Platinum Antitumor DrugsSemantic proximity Read ↗

Platinum Complexes as Anticancer AgentsSemantic proximity Read ↗

Cisplatin and platinum drugs at the molecular level. (Review).Semantic proximity Read ↗

Cisplatin resistance in cell models: evaluation of metallomic and biological predictive biomarkers to address early therapy failureSemantic proximity Read ↗

Genotoxicity effects in Cancer Patients: Evaluation by Micronucleus and Comet Assays and Correlation with Biochemical and Hematological IndicesSemantic proximity Read ↗

Pt-based drugs: the spotlight will be on proteinsSemantic proximity Read ↗

Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitroSemantic proximity Read ↗

Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted CytotoxicitySemantic proximity Read ↗

Fresh Platinum Complexes with Promising Antitumor ActivitySemantic proximity Read ↗

Oxidative Damage, Bleomycin, and Gamma Radiation Induce Different Types of DNA Strand Breaks in Normal Lymphocytes and Thymocytes: A Comet Assay StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.