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Article

Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2008

Eller Philipp, Hochegger Kathrin, Feuchtner Gudrun M, Zitt Emanuel, Tancevski Ivan, Ritsch Andreas, Kronenberg Florian, Rosenkranz Alexander R, Patsch Josef R, Mayer Gert

Abstract excerpt

BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized arterial calcification of infancy. We hypothesiz...

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Source

Identifiers

PMID: 17848394
DOI: 10.1093/ndt/gfm566

Genes

ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17848394-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure.PMID 17848394Read ↗

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism modulates developing of bone disorders in type 2 diabetes: A cross sectional study.Semantic proximity Read ↗

Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Homozygous splice-site variant in ENPP1 underlies generalized arterial calcification of infancy.Semantic proximity Read ↗

Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes.Semantic proximity Read ↗

Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population.Semantic proximity Read ↗

The role of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 in diabetic nephropathy.Semantic proximity Read ↗

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.Semantic proximity Read ↗

ENPP1 K121Q (rs1044498 C > A) genetic polymorphism confers a high risk of susceptibility to coronary heart disease: A PRISMA-compliant article.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

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