Article
Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2008
Eller Philipp, Hochegger Kathrin, Feuchtner Gudrun M, Zitt Emanuel, Tancevski Ivan, Ritsch Andreas, Kronenberg Florian, Rosenkranz Alexander R, Patsch Josef R, Mayer Gert
Abstract excerpt
BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates inorganic pyrophosphate, a solute that serves as an essential physiological inhibitor of calcification. Inactivating mutations of ENPP1 are associated with generalized arterial calcification of infancy. We hypothesized the ENPP1 K121Q variant to be associated with increased vascular calcification in patients with end-stage renal...
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