Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.

doi:10.1371/journal.pone.0118416

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Article

Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.

PloS one - 1 Jan 2015

Sortica Denise Alves, Buffon Marjorie Piucco, Souza Bianca Marmontel, Nicoletto Bruna Bellicanta, Santer Andressa, Assmann Tais Silveira, Crispim Daisy, Canani Luis Henrique

Abstract excerpt

The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism...

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PMID: 25794151
DOI: 10.1371/journal.pone.0118416
PMCID: PMC4368055

Genes

ENPP1

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Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.PMID 25794151Read ↗

ENPP1 K121Q polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis including 11,855 subjects.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Role of ENPP1 Gene Variants in the Susceptibility to Diabetic Nephropathy in Patients with type 2 Diabetes Mellitus.Semantic proximity Read ↗

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.Semantic proximity Read ↗

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ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes in North Indians.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism modulates developing of bone disorders in type 2 diabetes: A cross sectional study.Semantic proximity Read ↗

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New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.Semantic proximity Read ↗

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