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Article

Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.

The Journal of biological chemistry - 21 May 2004

Zhang Huifang M, Rao Jaladanki N, Guo Xin, Liu Lan, Zou Tongtong, Turner Douglas J, Wang Jian-Ying

Abstract excerpt

Apoptosis plays a critical role in the maintenance of gut mucosal homeostasis and is regulated by numerous factors including polyamines. Although the exact roles of polyamines in apoptotic pathway are still unclear, inhibition of polyamine synthesis promotes the resistance of intestinal epithelial cells to apoptosis. Akt is a serine-threonine kinase that has been established as an important intracellular...

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PMID: 15024023
DOI: 10.1074/jbc.M314337200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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