Article
Oligotyping of celiac multiplex families with the 11th International Histocompatibility Workshop reagents.
Tissue antigens - 1 Nov 1991
Petronzelli F, Ferrante P, Triglione P, Bonamico M, Mazzilli M C
Abstract excerpt
Using PCR and SSO probes from the 11th International Histocompatibility Workshop, we oligotyped for HLA-DRB1 gene and DQA1*0501, DQB1*0201 alleles 10 celiac families each with 2 affected children. All families belong to the Italian population except for one, whose mother is originally from Cape Verde island. 8/10 sibling pairs share the DQA1*0501/B1*0201 heterodimer, inherited in cis or in trans arrangement. All...
Topics
- Adult
- Celiac Disease
- Child
- Disease Susceptibility
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DR Antigens
- Histocompatibility Testing
- Humans
- Italy