Article
The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis.
Annals of the rheumatic diseases - 1 Nov 2008
Albers H M, Kurreeman F A S, Houwing-Duistermaat J J, Brinkman D M C, Kamphuis S S M, Girschick H J, Wouters C, Van Rossum M A J, Verduijn W, Toes R E M, Huizinga T W J, Schilham M W, ten Cate R
Abstract excerpt
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently, we identified the TRAF1/C5 region (located on chromosome 9q33-34) as a risk factor for rheumatoid arthritis (RA) (p(combined) = 1.4 x 10(-8)). In the present study the association of the TRAF1/C5 region with the susceptibility to JIA was investigated. METHODS: A case-control...
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