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Article

Fine-tuning Tumor Immunity with Integrin Trans-regulation.

Cancer immunology research - 1 Jun 2015

Cantor Joseph M, Rose David M, Slepak Marina, Ginsberg Mark H

Abstract excerpt

Inefficient T-cell homing to tissues limits adoptive T-cell immunotherapy of solid tumors. αLβ2 and α4β1 integrins mediate trafficking of T cells into tissues via engagement of ICAM-1 and VCAM-1, respectively. Inhibiting protein kinase A (PKA)-mediated phosphorylation of α4 integrin in cells resu...

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Source

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Identifiers

PMID: 25600437
DOI: 10.1158/2326-6066.CIR-13-0226
PMCID: PMC5955000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25600437-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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