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Article

PITX2 and beta-catenin interactions regulate Lef-1 isoform expression.

Molecular and cellular biology - 1 Nov 2007

Amen Melanie, Liu Xiaoming, Vadlamudi Usha, Elizondo Gabriela, Diamond Evan, Engelhardt John F, Amendt Brad A

Abstract excerpt

Lef-1 and PITX2 function in the Wnt signaling pathway by recruiting and interacting with beta-catenin to activate target genes. Chromatin immunoprecipitation (ChIP) assays identified the Lef-1 promoter as a PITX2 downstream target. Transgenic mice expressing LacZ driven by the 2.5-kb LEF-1 promoter demonstrated expression in the tooth epithelium correlated with endogenous Lef-1 FL epithelial expression. PITX2...

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Source

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Identifiers

PMID: 17785445
DOI: 10.1128/MCB.00315-07
PMCID: PMC2169058

Genes

PITX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PITX2 and beta-catenin interactions regulate Lef-1 isoform expression.PMID 17785445Read ↗

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