Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2

1 Apr 2010

Abstract excerpt

Pituitary homeobox 2 (PITX2), a Paired-like homeodomain transcription factor and a downstream effector of β-catenin signaling, plays substantial roles in normal embryonic development but its possible involvement in tumorigenesis was unknown. In this study, we extend its function in human cancer. Remarkably, we found that PITX2 was frequently expressed in human follicular cell-derived (papillary, follicular and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cancer-related Molecular Pathways
Share to Thyroid Cancer Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20372070
DOI: 10.4161/cc.9.7.11126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2PMID 20372070Read ↗

Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.Semantic proximity Read ↗

Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinomaSemantic proximity Read ↗

Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma.Semantic proximity Read ↗

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid CancerSemantic proximity Read ↗

Paired-Box Gene 8 (PAX8) and Its Association With Epithelial CarcinomasSemantic proximity Read ↗

LncRNA HOTAIR impairs the prognosis of papillary thyroid cancer via regulating cellular malignancy and epigenetically suppressing DLX1Semantic proximity Read ↗

E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycleSemantic proximity Read ↗

An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.Semantic proximity Read ↗

Expression of the members of the Ptx family of transcription factors in human pituitary adenomas.Semantic proximity Read ↗

The PAX8 / PPARγ Fusion Oncogene as a Potential Therapeutic Target in Follicular Thyroid CarcinomaSemantic proximity Read ↗

Immunohistochemical analysis of thyroid‐specific transcription factors in thyroid tumorsSemantic proximity Read ↗

UBE2T promotes PTC progression by activating the JAK/STAT3 pathway via negative regulation of SOCS2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.