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Article

Bone mass in prepubertal boys is associated with a Gln223Arg amino acid substitution in the leptin receptor.

The Journal of clinical endocrinology and metabolism - 1 Nov 2007

Richert Laura, Chevalley Thierry, Manen Danielle, Bonjour Jean-Philippe, Rizzoli René, Ferrari Serge

Abstract excerpt

OBJECTIVE: The contribution of leptin to bone mass acquisition in humans remains unclear. We investigated the association of the Gln223Arg polymorphism in the leptin receptor gene (LEPR) with bone mineral content (BMC) and areal bone mineral density (aBMD) in prepubertal boys and LEPR interaction with vitamin D receptor (VDR) genotypes (Bsm1 and Fok1). DESIGN: In a cross-sectional design with a longitudinal...

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Source

Identifiers

PMID: 17785359
DOI: 10.1210/jc.2007-0932

Genes

LEPR
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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