Article
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Oral oncology - 1 Jul 2006
Sathyan K M, Nalinakumari K R, Abraham Thomas, Kannan S
Abstract excerpt
Although tobacco usage and alcohol consumption are the major risk factors for oral cancer, there are individual variations in genetic susceptibility to oral cancer. The Ras pathway plays an important role in oral carcinogenesis. High percentage of Ras mutation in oral carcinoma was reported from India. Cyclin D1, a downstream member of the Ras pathway, was also shown to be overexpressed in the majority of oral...
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